OSI-027
Product Specifications
CAS Number
936890-98-1
Synonyms
ASP4786, CERC 006, AEVI-006
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
COC1=CC=CC2=C1NC (=C2) C3=C4C (=NC=NN4C (=N3) C5CCC (CC5) C (=O) O) N
Molecular Formula
C21H22N6O3
Additionnal Information
OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.
Storage Conditions
2 years -80 in solvent
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