Cyclosporin A
Product Specifications
CAS Number
59865-13-3
Synonyms
Cyclosporine A, Cyclosporine, Ciclosporin, CsA, NSC 290193
Target
Immunology & Inflammation related
Applications
Immunology & Inflammation
Smiles
CCC1C (=O) N (CC (=O) N (C (C (=O) NC (C (=O) N (C (C (=O) NC (C (=O) NC (C (=O) N (C (C (=O) N (C (C (=O) N (C (C (=O) N (C (C (=O) N1) C (C (C) CC=CC) O) C) C (C) C) C) CC (C) C) C) CC (C) C) C) C) C) CC (C) C) C) C (C) C) CC (C) C) C) C
Molecular Formula
C62H111N11O12
Additionnal Information
Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
Storage Conditions
2 years -80 in solvent
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