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Berberine chloride

Product Specifications

CAS Number

633-65-8

Synonyms

NSC 646666, Natural Yellow 18 chloride

Target

Anti-infection

Applications

Microbiology

Molecular Formula

C20H18NO4.Cl

Additionnal Information

Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

Storage Conditions

2 years -80 in solvent

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