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Buparlisib (BKM120)

Product Specifications

CAS Number

944396-07-0

Synonyms

NVP-BKM120

Target

PI3K

Applications

PI3K/Akt/mTOR

Smiles

C1COCCN1C2=NC (=NC (=C2) C3=CN=C (C=C3C (F) (F) F) N) N4CCOCC4

Molecular Formula

C18H21F3N6O2

Additionnal Information

Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.

Storage Conditions

2 years -80 in solvent

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