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AMG-47a

Product Specifications

CAS Number

882663-88-9

Target

Src

Applications

Protein Tyrosine Kinase

Smiles

CC1=C (C=C (C=C1) C (=O) NC2=CC=CC (=C2) C (F) (F) F) C3=CC4=CN=C (N=C4C=C3) NCCN5CCOCC5

Molecular Formula

C29H28F3N5O2

Additionnal Information

AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.

Storage Conditions

3 years -20°C powder

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