Fostamatinib (R788) disodium
Product Specifications
CAS Number
1025687-58-4
Synonyms
Tamatinib Fosdium
Target
Syk
Applications
Protein Tyrosine Kinase
Smiles
CC1 (C (=O) N (C2=C (O1) C=CC (=N2) NC3=NC (=NC=C3F) NC4=CC (=C (C (=C4) OC) OC) OC) COP (=O) ([O-]) [O-]) C.[Na+].[Na+]
Molecular Formula
C23H24FN6O9P.2Na
Additionnal Information
Fostamatinib disodium (R788, Tamatinib Fosdium), a prodrug of the active metabolite R406, is a Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 3.
Storage Conditions
2 years -80 in solvent
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