SGI-1776 free base
Product Specifications
CAS Number
1025065-69-3
Target
Pim
Applications
JAK/STAT
Smiles
CN1CCC (CC1) CNC2=NN3C (=NC=C3C4=CC (=CC=C4) OC (F) (F) F) C=C2
Molecular Formula
C20H22F3N5O
Additionnal Information
SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.
Storage Conditions
2 years -80 in solvent
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