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SGI-1776 free base

Product Specifications

CAS Number

1025065-69-3

Target

Pim

Applications

JAK/STAT

Smiles

CN1CCC (CC1) CNC2=NN3C (=NC=C3C4=CC (=CC=C4) OC (F) (F) F) C=C2

Molecular Formula

C20H22F3N5O

Additionnal Information

SGI-1776 free base is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. SGI-1776 induces apoptosis and autophagy.

Storage Conditions

2 years -80 in solvent

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