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Ixazomib (MLN2238)

Product Specifications

CAS Number

1072833-77-2

Target

Proteasome

Applications

Proteases

Smiles

B (C (CC (C) C) NC (=O) CNC (=O) C1=C (C=CC (=C1) Cl) Cl) (O) O

Molecular Formula

C14H19BCl2N2O4

Additionnal Information

Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.

Storage Conditions

2 years -80 in solvent

Frequently Asked Questions

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