PF-4708671
Product Specifications
CAS Number
1255517-76-0
Target
S6 Kinase
Applications
MAPK
Smiles
CCC1=CN=CN=C1N2CCN (CC2) CC3=NC4=C (N3) C=C (C=C4) C (F) (F) F
Molecular Formula
C19H21F3N6
Additionnal Information
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.
Storage Conditions
2 years -80 in solvent
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