Sonidegib

Product Specifications

CAS Number

956697-53-3

Synonyms

NVP-LDE225, Erismodegib

Target

Hedgehog/Smoothened

Applications

Stem Cells & Wnt

Smiles

CC1CN (CC (O1) C) C2=NC=C (C=C2) NC (=O) C3=CC=CC (=C3C) C4=CC=C (C=C4) OC (F) (F) F

Molecular Formula

C26H26F3N3O3

Additionnal Information

Sonidegib is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively. Phase 3.

Storage Conditions

2 years -80 in solvent

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