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Neratinib

Product Specifications

CAS Number

698387-09-6

Synonyms

HKI-272

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CCOC1=C (C=C2C (=C1) N=CC (=C2NC3=CC (=C (C=C3) OCC4=CC=CC=N4) Cl) C#N) NC (=O) C=CCN (C) C

Molecular Formula

C30H29ClN6O3

Additionnal Information

Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.

Storage Conditions

2 years -80 in solvent

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