Neratinib
Product Specifications
CAS Number
698387-09-6
Synonyms
HKI-272
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
CCOC1=C (C=C2C (=C1) N=CC (=C2NC3=CC (=C (C=C3) OCC4=CC=CC=N4) Cl) C#N) NC (=O) C=CCN (C) C
Molecular Formula
C30H29ClN6O3
Additionnal Information
Neratinib is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.
Storage Conditions
2 years -80 in solvent
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