Pioglitazone HCl
Product Specifications
CAS Number
112529-15-4
Synonyms
AD-4833, U-72107E
Target
P450 (e.g. CYP17)
Applications
Metabolism
Smiles
CCC1=CN=C (C=C1) CCOC2=CC=C (C=C2) CC3C (=O) NC (=O) S3.Cl
Molecular Formula
C19H20N2O3S.HCl
Additionnal Information
Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP) 2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
Storage Conditions
2 years -80 in solvent
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