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PF-573228

Product Specifications

CAS Number

869288-64-2

Target

FAK

Applications

Protein Tyrosine Kinase

Smiles

CS (=O) (=O) C1=CC=CC (=C1) CNC2=NC (=NC=C2C (F) (F) F) NC3=CC4=C (C=C3) NC (=O) CC4

Molecular Formula

C22H20F3N5O3S

Additionnal Information

PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. PF-573228 induces apoptosis.

Storage Conditions

2 years -80 in solvent

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