Raltegravir
Product Specifications
CAS Number
518048-05-0
Synonyms
MK-0518
Target
Integrase
Applications
Microbiology
Smiles
CC1=NN=C (O1) C (=O) NC (C) (C) C2=NC (=C (C (=O) N2C) O) C (=O) NCC3=CC=C (C=C3) F
Molecular Formula
C20H21FN6O5
Additionnal Information
Raltegravir is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.
Storage Conditions
2 years -80 in solvent
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