Semagacestat (LY450139)
Product Specifications
CAS Number
425386-60-3
Target
Secretase
Applications
Stem Cells & Wnt
Smiles
CC (C) C (C (=O) NC (C) C (=O) NC1C2=CC=CC=C2CCN (C1=O) C) O
Molecular Formula
C19H27N3O4
Additionnal Information
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.
Storage Conditions
2 years -80 in solvent
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