Lumacaftor (VX-809)
Product Specifications
CAS Number
936727-05-8
Synonyms
VRT 826809
Target
CFTR
Applications
Transmembrane Transporters
Smiles
CC1=C (N=C (C=C1) NC (=O) C2 (CC2) C3=CC4=C (C=C3) OC (O4) (F) F) C5=CC (=CC=C5) C (=O) O
Molecular Formula
C24H18F2N2O5
Additionnal Information
Lumacaftor (VX-809, VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR) maturation, EC50 of 0.1 μM in fisher rat thyroid cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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