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BMS-777607

Product Specifications

CAS Number

1025720-94-8

Synonyms

BMS 817378

Target

Axl

Applications

Protein Tyrosine Kinase

Smiles

CCOC1=C (C (=O) N (C=C1) C2=CC=C (C=C2) F) C (=O) NC3=CC (=C (C=C3) OC4=C (C (=NC=C4) N) Cl) F

Molecular Formula

C25H19ClF2N4O4

Additionnal Information

BMS-777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck, VEGFR-2, and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.

Storage Conditions

2 years -80 in solvent

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