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R406 (free base)

Product Specifications

CAS Number

841290-80-0

Target

Syk

Applications

Protein Tyrosine Kinase

Smiles

CC1 (C (=O) NC2=C (O1) C=CC (=N2) NC3=NC (=NC=C3F) NC4=CC (=C (C (=C4) OC) OC) OC) C

Molecular Formula

C22H23FN6O5

Additionnal Information

R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. R406 (free base) triggers apoptosis. Phase 1.

Storage Conditions

2 years -80 in solvent

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