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Ispinesib (SB-715992)

Product Specifications

CAS Number

336113-53-2

Synonyms

CK0238273

Target

Kinesin

Applications

Cytoskeletal Signaling

Smiles

CC1=CC=C (C=C1) C (=O) N (CCCN) C (C2=NC3=C (C=CC (=C3) Cl) C (=O) N2CC4=CC=CC=C4) C (C) C

Molecular Formula

C30H33ClN4O2

Additionnal Information

Ispinesib (SB-715992, CK0238273) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with Ki app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. Ispinesib induces mitotic arrest and apoptotic cell death.

Storage Conditions

2 years -80 in solvent

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