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L-2-Hydroxyglutaric acid disodium

Product Specifications

CAS Number

63512-50-5

Synonyms

(S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG

Target

Histone Demethylase

Applications

Epigenetics

Smiles

[Na+].[Na+].OC (CCC ([O-]) =O) C ([O-]) =O

Molecular Formula

C5H6Na2O5

Additionnal Information

L-2-Hydroxyglutaric acid disodium ((S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.

Storage Conditions

3 years -20°C powder

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