Vemurafenib (PLX4032)
Product Specifications
CAS Number
918504-65-1
Synonyms
RG7204, RO5185426, PLX4032
Target
Raf
Applications
MAPK
Smiles
CCCS (=O) (=O) NC1=C (C (=C (C=C1) F) C (=O) C2=CNC3=C2C=C (C=N3) C4=CC=C (C=C4) Cl) F
Molecular Formula
C23H18ClF2N3O3S
Additionnal Information
Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy.
Storage Conditions
3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent
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