TMZ (Temozolomide)
Product Specifications
CAS Number
85622-93-1
Synonyms
NSC 362856, CCRG 81045, Methazolastone
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
CN1C (=O) N2C=NC (=C2N=N1) C (=O) N
Molecular Formula
C6H6N6O2
Additionnal Information
TMZ (Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.
Storage Conditions
In dark and seal
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