Flavopiridol (Alvocidib)
Product Specifications
CAS Number
146426-40-6
Synonyms
NSC 649890, HMR-1275, L86-8275
Target
CDK
Applications
Cell Cycle
Smiles
CN1CCC (C (C1) O) C2=C (C=C (C3=C2OC (=CC3=O) C4=CC=CC=C4Cl) O) O
Molecular Formula
C21H20ClNO5
Additionnal Information
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.
Storage Conditions
2 years -80 in solvent
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