Flavopiridol (Alvocidib)
Product Specifications
CAS Number
146426-40-6
Synonyms
NSC 649890, HMR-1275, L86-8275
Target
CDK
Applications
Cell Cycle
Smiles
CN1CCC (C (C1) O) C2=C (C=C (C3=C2OC (=CC3=O) C4=CC=CC=C4Cl) O) O
Molecular Formula
C21H20ClNO5
Additionnal Information
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC741429-100 1x 100 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940352-500 1x 500 µL
CD31 / PECAM-1 (158-2B3), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471820-500 1x 500 µL
Ep-CAM / CD326 (Epithelial Marker) (rVU-1D9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740676-100 1x 100 µL
MUC18 / Mucin 18 / CD146 (OJ79c), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040034-100 1x 100 µL
Cytokeratin 8/18 (C-51), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040460-100 1x 100 µL
CD44 Standard (156-3C11), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details