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Methotrexate

Product Specifications

CAS Number

59-05-2

Synonyms

NCI-C04671, Amethopterin, CL14377, WR19039

Target

DHFR

Applications

Cell Cycle

Smiles

CN (CC1=CN=C2C (=N1) C (=NC (=N2) N) N) C3=CC=C (C=C3) C (=O) NC (CCC (=O) O) C (=O) O

Molecular Formula

C20H22N8O5

Additionnal Information

Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase (DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.

Storage Conditions

3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent

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