Tivozanib
Product Specifications
CAS Number
475108-18-0
Synonyms
AV-951, KRN-951
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=NO1) NC (=O) NC2=C (C=C (C=C2) OC3=C4C=C (C (=CC4=NC=C3) OC) OC) Cl
Molecular Formula
C22H19ClN4O5
Additionnal Information
Tivozanib is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM, and also inhibits PDGFR and c-Kit, low activity observed against FGFR-1, Flt3, c-Met, EGFR and IGF-1R. Phase 3.
Storage Conditions
2 years -80 in solvent
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