Lenvatinib
Product Specifications
CAS Number
417716-92-8
Synonyms
E7080
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
COC1=CC2=NC=CC (=C2C=C1C (=O) N) OC3=CC (=C (C=C3) NC (=O) NC4CC4) Cl
Molecular Formula
C21H19ClN4O4
Additionnal Information
Lenvatinib is a multi-target inhibitor, mostly for VEGFR2 (KDR) /VEGFR3 (Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.
Storage Conditions
2 years -80 in solvent
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