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PLX-4720

Product Specifications

CAS Number

918505-84-7

Target

Raf

Applications

MAPK

Smiles

CCCS (=O) (=O) NC1=C (C (=C (C=C1) F) C (=O) C2=CNC3=C2C=C (C=N3) Cl) F

Molecular Formula

C17H14ClF2N3O3S

Additionnal Information

PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1 (Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

Storage Conditions

2 years -80 in solvent

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