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Pemetrexed disodium

Product Specifications

CAS Number

150399-23-8

Synonyms

LY-231514 disodium

Target

DHFR

Applications

Cell Cycle

Smiles

C1=CC (=CC=C1CCC2=CNC3=C2C (=O) NC (=N3) N) C (=O) NC (CCC (=O) [O-]) C (=O) [O-].[Na+].[Na+]

Molecular Formula

C20H19N5Na2O6

Additionnal Information

Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.

Storage Conditions

2 years -80 in solvent

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