Cabozantinib (XL184)
Product Specifications
CAS Number
849217-68-1
Synonyms
BMS-907351
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
COC1=CC2=C (C=CN=C2C=C1OC) OC3=CC=C (C=C3) NC (=O) C4 (CC4) C (=O) NC5=CC=C (C=C5) F
Molecular Formula
C28H24FN3O5
Additionnal Information
Cabozantinib (XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.
Storage Conditions
2 years -80 in solvent
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