XL147 analogue
Product Specifications
CAS Number
956958-53-5
Synonyms
SAR245408
Target
PI3K
Applications
PI3K/Akt/mTOR
Smiles
CC1=CC=C (C=C1) S (=O) (=O) NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4
Molecular Formula
C21H16N6O2S2
Additionnal Information
XL147 analogue (SAR245408) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. XL147 analogue induces apoptosis. Phase 1/2.
Storage Conditions
2 years -80 in solvent
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