SB202190
Product Specifications
CAS Number
152121-30-7
Synonyms
FHPI
Target
P38 MAPK
Applications
MAPK
Smiles
C1=CC (=CC=C1C2=NC (=C (N2) C3=CC=NC=C3) C4=CC=C (C=C4) F) O
Molecular Formula
C20H14N3OF
Additionnal Information
SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.
Storage Conditions
2 years -80 in solvent
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