Entinostat (MS-275)
Product Specifications
CAS Number
209783-80-2
Synonyms
SNDX-275
Target
HDAC
Applications
DNA Damage/DNA Repair
Smiles
C1=CC=C (C (=C1) N) NC (=O) C2=CC=C (C=C2) CNC (=O) OCC3=CN=CC=C3
Molecular Formula
C21H20N4O3
Additionnal Information
Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis. Phase 3.
Storage Conditions
2 years -80 in solvent
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