Vandetanib
Product Specifications
CAS Number
443913-73-3
Synonyms
ZD6474
Target
VEGFR
Applications
Protein Tyrosine Kinase
Smiles
CN1CCC (CC1) COC2=C (C=C3C (=C2) N=CN=C3NC4=C (C=C (C=C4) Br) F) OC
Molecular Formula
C22H24BrFN4O2
Additionnal Information
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay. It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM, respectively. Not sensitive to PDGFRβ, Flt1, Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM. No activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R with IC50 above 10 μM. Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS) .
Storage Conditions
2 years -80 in solvent
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