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Sunitinib malate

Product Specifications

CAS Number

341031-54-7

Synonyms

SU11248 malate

Target

C-Kit

Applications

Protein Tyrosine Kinase

Smiles

CCN (CC) CCNC (=O) C1=C (NC (=C1C) C=C2C3=C (C=CC (=C3) F) NC2=O) C.C (C (C (=O) O) O) C (=O) O

Molecular Formula

C22H27FN4O2.C4H6O5

Additionnal Information

Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.

Storage Conditions

2 years -80 in solvent

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