Lenalidomide
Product Specifications
CAS Number
191732-72-6
Synonyms
CC-5013
Target
TNF-alpha
Applications
Apoptosis
Smiles
C1CC (=O) NC (=O) C1N2CC3=C (C2=O) C=CC=C3N
Molecular Formula
C13H13N3O3
Additionnal Information
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Storage Conditions
2 years -80 in solvent
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