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Bortezomib

Product Specifications

CAS Number

179324-69-7

Synonyms

LDP-341, MLM341, NSC 681239, PS-341, BTZ

Target

Proteasome

Applications

Proteases

Smiles

B (C (CC (C) C) NC (=O) C (CC1=CC=CC=C1) NC (=O) C2=NC=CN=C2) (O) O

Molecular Formula

C19H25BN4O4

Additionnal Information

Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.

Storage Conditions

3 years -20°C (in the dark) powder1 year -80°C (in the dark) in solvent

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