Linifanib (ABT-869)
Product Specifications
CAS Number
796967-16-3
Synonyms
AL39324, RG3635
Target
CSF-1R
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC (=C (C=C1) F) NC (=O) NC2=CC=C (C=C2) C3=C4C (=CC=C3) NN=C4N
Molecular Formula
C21H18FN5O
Additionnal Information
Linifanib (ABT-869, AL39324, RG3635) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR, CSF-1R, Flt-1/3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM/4 nM and 66 nM respectively, mostly effective in mutant kinase-dependent cancer cells (i.e. FLT3) . Linifanib (ABT-869) induces autophagy and apoptosis. Phase 3.
Storage Conditions
2 years -80 in solvent
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