Navitoclax (ABT-263)
Product Specifications
CAS Number
923564-51-6
Target
Bcl-2
Applications
Apoptosis
Smiles
CC1 (CCC (=C (C1) CN2CCN (CC2) C3=CC=C (C=C3) C (=O) NS (=O) (=O) C4=CC (=C (C=C4) NC (CCN5CCOCC5) CSC6=CC=CC=C6) S (=O) (=O) C (F) (F) F) C7=CC=C (C=C7) Cl) C
Molecular Formula
C47H55ClF3N5O6S3
Additionnal Information
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.
Storage Conditions
2 years -80 in solvent
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