Isoliquiritin apioside

Product Specifications

CAS Number

120926-46-7

Synonyms

ISLA, ILA

Target

MMP

Applications

Proteases

Smiles

C1C (C (C (O1) OC2C (C (C (OC2OC3=CC=C (C=C3) C=CC (=O) C4=C (C=C (C=C4) O) O) CO) O) O) O) (CO) O

Molecular Formula

C26H30O13

Additionnal Information

Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.