SP141
Product Specifications
CAS Number
1253491-42-7
Target
MDM2/MDMX
Applications
Apoptosis
Smiles
COC1=CC2=C (C=C1) NC3=C2C=CN=C3C4=CC=CC5=CC=CC=C54
Molecular Formula
C22H16N2O
Additionnal Information
SP141 is a new class of MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation, and reduces levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation and ability to form tumors in nude mice. SP141 inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM (0.38–0.50 μM) in a p53-independent manner.
Storage Conditions
3 years -20°C powder
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