SR-717 lithium

Product Specifications

CAS Number

2375421-09-1

Target

STING

Applications

Immunology & Inflammation

Smiles

[Li]OC (=O) C1=C (NC (=O) C2=NN=C (C=C2) [N]3C=CN=C3) C=C (F) C (=C1) F

Molecular Formula

C15H8F2LiN5O3

Additionnal Information

SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.