SKI-V
Product Specifications
CAS Number
24418-86-8
Target
SPHK
Applications
Immunology & Inflammation
Smiles
C1=CC=C2C (=C1) C (=O) C (=CC3=CC (=C (C=C3) O) O) O2
Molecular Formula
C15H10O4
Additionnal Information
SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
Storage Conditions
3 years -20°C powder
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