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Apilimod mesylate

Product Specifications

CAS Number

870087-36-8

Synonyms

STA-5326 mesylate

Target

Interleukins

Applications

Immunology & Inflammation

Smiles

CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4.CS (=O) (=O) O.CS (=O) (=O) O

Molecular Formula

C25H34N6O8S2

Additionnal Information

Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.

Storage Conditions

3 years -20°C powder

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