Isuzinaxib (APX-115 free base)
Product Specifications
CAS Number
1270084-92-8
Synonyms
Ewha-18278 free base
Target
NADPH-oxidase
Applications
Immunology & Inflammation
Smiles
CCCC1=C (NN (C1=O) C2=CC=CC=N2) C3=CC=CC=C3
Molecular Formula
C17H17N3O
Additionnal Information
Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
Storage Conditions
3 years -20°C powder
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