TP0463518

Product Specifications

CAS Number

1558021-37-6

Target

HIF

Applications

Angiogenesis

Smiles

C1CN (C (=O) C (=C1O) C (=O) NCC (=O) O) CC2=CN=C (C=C2) OC3=CC=C (C=C3) Cl

Molecular Formula

C20H18ClN3O6

Additionnal Information

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with Ki of 5.3 nM for human PHD2. TP0463518 inhibits human PHD1, human PHD3 and monkey PHD2 with IC50 of 18 nM, 63 nM and 22 nM, respectively.

Storage Conditions

3 years -20°C powder

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