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Canertinib dihydrochloride

Product Specifications

CAS Number

289499-45-2

Synonyms

CI-1033 dihydrochloride, PD-183805 dihydrochloride

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

C=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OCCCN4CCOCC4.Cl.Cl

Molecular Formula

C24H27Cl3FN5O3

Additionnal Information

Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR and ErbB2 autophosphorylation with IC50 of 7.4 nM and 9 nM, respectively.

Storage Conditions

3 years -20°C powder

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