Canertinib dihydrochloride
Product Specifications
CAS Number
289499-45-2
Synonyms
CI-1033 dihydrochloride, PD-183805 dihydrochloride
Target
EGFR
Applications
Protein Tyrosine Kinase
Smiles
C=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OCCCN4CCOCC4.Cl.Cl
Molecular Formula
C24H27Cl3FN5O3
Additionnal Information
Canertinib (CI-1033, PD-183805, compound 18) dihydrochloride is a potent and irreversible inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Canertinib dihydrochloride inhibits cellular EGFR and ErbB2 autophosphorylation with IC50 of 7.4 nM and 9 nM, respectively.
Storage Conditions
3 years -20°C powder
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